Gene MYBPC3

Also known as

myosin binding protein C cardiac, cardiac MyBP-C, cMyBP-C, CMH4

Overview

MYBPC3 (Myosin Binding Protein C, Cardiac) encodes a protein that is a major structural component of cardiac muscle sarcomeres. Cardiac myosin binding protein C helps regulate muscle contraction by modulating the interaction between myosin and actin. It acts as a molecular brake that controls the speed and efficiency of heart muscle contraction.

Mutations in MYBPC3 are the most common cause of hypertrophic cardiomyopathy (HCM), accounting for 40-50% of genetic cases. HCM is characterized by abnormal thickening of the heart muscle that can lead to heart failure, arrhythmias, and sudden cardiac death. Many MYBPC3 mutations cause haploinsufficiency, leading to reduced levels of functional protein.

Understanding your MYBPC3 genetic status provides critical insights into hereditary heart disease risk. This information is particularly important for individuals with family history of HCM, sudden cardiac death, or unexplained heart failure, as early detection allows for appropriate monitoring and preventive measures.

NutraHacker Raw DNA Analysis Products that include this gene

• Carrier Status and Drug Response Report
• Whole Genome Sequencing Critical Genetics Report

Upload raw DNA data to get your very own analysis of gene MYBPC3 through your personalized DNA reports.