Gene MMP1
Back to Curriculum
Also known as
matrix metalloproteinase 1, collagenase-1, interstitial collagenase, fibroblast collagenaseOverview
MMP1 (Matrix Metalloproteinase 1) encodes a collagenase that cleaves interstitial collagens (types I, II, and III) in the extracellular matrix. This enzyme plays essential roles in tissue remodeling, wound healing, and normal turnover of connective tissue. In the skin, MMP1 is induced by UV radiation and is a major driver of photoaging.The -1607 1G/2G promoter polymorphism in MMP1 affects gene expression, with the 2G allele associated with higher MMP1 production. Higher MMP1 levels contribute to accelerated collagen breakdown and skin aging, particularly after sun exposure. This variant has also been associated with arthritis severity and cancer progression through effects on matrix degradation.
Understanding your MMP1 genetic status provides insights into collagen turnover and skin aging susceptibility. This information is valuable for understanding photoaging risk and guiding preventive skincare strategies, particularly sun protection and collagen-supporting interventions.