Gene MFGE8
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Also known as
milk fat globule EGF factor 8, lactadherin, SED1, BA46Overview
MFGE8 (Milk Fat Globule EGF Factor 8) encodes lactadherin, a secreted glycoprotein found in milk fat globules and various tissues. Lactadherin plays multiple roles including facilitating engulfment of apoptotic cells by macrophages, promoting cell adhesion, and supporting mammary gland development. In breast milk, MFGE8 contributes to fat globule secretion and may support infant gut health.Variants in MFGE8 can affect lactadherin production and function, potentially influencing breast milk composition and quality. The protein also has anti-inflammatory properties and plays roles in wound healing and tissue regeneration. MFGE8 levels in breast milk may affect infant immune development and fat absorption.
Understanding your MFGE8 genetic status provides insights into breast milk protein composition and cellular clearance mechanisms. This information is particularly relevant for understanding breast milk quality, infant nutrition during breastfeeding, and potentially wound healing capacity.