Gene MEN1
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Also known as
menin, multiple endocrine neoplasia type 1, MEAIOverview
MEN1 (Multiple Endocrine Neoplasia Type 1) encodes menin, a tumor suppressor protein involved in transcriptional regulation, DNA repair, and cell cycle control. Menin interacts with numerous proteins including transcription factors and chromatin-modifying complexes. It plays important roles in controlling cell proliferation in endocrine tissues.Mutations in MEN1 cause multiple endocrine neoplasia type 1, an autosomal dominant syndrome characterized by tumors of the parathyroid glands (leading to hyperparathyroidism), pituitary gland, and pancreatic islets. Most affected individuals develop hyperparathyroidism by age 50. Early detection through genetic testing allows for surveillance and early intervention.
Understanding your MEN1 genetic status provides insights into endocrine tumor susceptibility. This information is particularly important for individuals with family history of MEN1 or unexplained hyperparathyroidism, as it can guide screening protocols for associated tumors.