Gene MAX
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Also known as
MYC associated factor X, bHLHd4, myc-associated protein XOverview
MAX (MYC Associated Factor X) encodes a basic helix-loop-helix leucine zipper transcription factor that is the obligate dimerization partner for the MYC oncoprotein. MAX-MYC heterodimers activate transcription of genes involved in cell proliferation, growth, and metabolism. MAX also forms homodimers and heterodimers with MXD family proteins that repress MYC target genes.Germline mutations in MAX have been identified as a cause of hereditary pheochromocytoma and paraganglioma, neuroendocrine tumors arising from the adrenal medulla or sympathetic ganglia. MAX functions as a tumor suppressor, and loss of MAX function leads to uncontrolled MYC activity and cellular proliferation. Tumors with MAX mutations may be bilateral and metastatic.
Understanding your MAX genetic status provides insights into hereditary tumor predisposition. This information is particularly important for individuals with family history of pheochromocytoma or paraganglioma, enabling surveillance for early tumor detection and appropriate management.