Gene LTC4S

Also known as

leukotriene C4 synthase, LTC4 synthase

Overview

LTC4S (Leukotriene C4 Synthase) encodes an enzyme that conjugates leukotriene A4 with glutathione to form leukotriene C4, the first of the cysteinyl leukotrienes. Cysteinyl leukotrienes are potent mediators of bronchoconstriction, mucus secretion, and vascular permeability, playing central roles in asthma and allergic reactions.

The -444A/C promoter polymorphism in LTC4S has been associated with aspirin-exacerbated respiratory disease (AERD) and asthma severity. The C allele increases LTC4S expression, leading to higher cysteinyl leukotriene production. This variant may also influence response to leukotriene modifier drugs like montelukast.

Understanding your LTC4S genetic status provides insights into cysteinyl leukotriene production and allergic inflammation. This information is particularly relevant for understanding asthma severity, aspirin sensitivity, and potential response to leukotriene-targeting therapies.

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