Gene LTA4H

Also known as

leukotriene A4 hydrolase, LTA-4 hydrolase

Overview

LTA4H (Leukotriene A4 Hydrolase) encodes an enzyme that converts leukotriene A4 (LTA4) to leukotriene B4 (LTB4), a potent proinflammatory lipid mediator. LTB4 is a powerful chemoattractant for neutrophils and promotes inflammation in conditions such as asthma, arthritis, and inflammatory bowel disease.

Variants in LTA4H have been associated with susceptibility to myocardial infarction and stroke, particularly in certain populations. The gene also plays a role in the inflammatory response to infection and has been implicated in tuberculosis susceptibility. Inhibitors of LTA4H are being investigated as anti-inflammatory agents for various conditions.

Understanding your LTA4H genetic status provides insights into leukotriene-mediated inflammation and related disease susceptibility. This information is relevant for understanding inflammatory responses and cardiovascular risk.

Upload raw DNA data to get your very own analysis of gene LTA4H through your personalized DNA reports.