Gene LPL
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Also known as
lipoprotein lipase, LIPD, clearing factor lipaseOverview
LPL (Lipoprotein Lipase) encodes an enzyme that hydrolyzes triglycerides in circulating lipoproteins (chylomicrons and VLDL), releasing fatty acids for uptake by tissues. LPL is attached to capillary endothelium in muscle and adipose tissue, where it plays a central role in lipid metabolism and energy homeostasis.Mutations in LPL cause familial lipoprotein lipase deficiency, characterized by severe hypertriglyceridemia from infancy, recurrent pancreatitis, eruptive xanthomas, and hepatosplenomegaly. Common LPL variants also influence triglyceride levels and HDL cholesterol in the general population, affecting cardiovascular disease risk. The S447X variant is associated with favorable lipid profiles and reduced coronary risk.
Understanding your LPL genetic status provides insights into triglyceride metabolism and cardiovascular risk. This information is relevant for understanding lipid levels, fat metabolism, and can guide dietary fat recommendations.