Gene LIPC

Also known as

HL, HTGL, hepatic lipase, lipase C

Overview

LIPC (Lipase C, Hepatic Type) encodes hepatic lipase, an enzyme that hydrolyzes triglycerides and phospholipids in lipoprotein particles. Hepatic lipase plays key roles in HDL metabolism, converting larger HDL2 particles to smaller HDL3, and in the conversion of intermediate-density lipoproteins (IDL) to LDL. It is synthesized in the liver and bound to hepatic endothelium.

Variants in LIPC significantly influence HDL cholesterol levels. The -514C/T promoter polymorphism affects gene expression, with the T allele associated with lower hepatic lipase activity and higher HDL cholesterol. However, the relationship between LIPC variants and cardiovascular risk is complex and may depend on dietary factors, particularly fat intake.

Understanding your LIPC genetic status provides insights into lipid metabolism and HDL regulation. This information may help personalize dietary recommendations, as individuals with certain variants may respond differently to dietary fat modifications.

NutraHacker Raw DNA Analysis Products that include this gene

• Fitness Report

Upload raw DNA data to get your very own analysis of gene LIPC through your personalized DNA reports.