Gene LAMB3
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Also known as
laminin subunit beta 3, nicein beta chain, kalinin beta chain, BM600-125KDOverview
LAMB3 (Laminin Subunit Beta 3) encodes the beta-3 chain of laminin-332, a major component of the basement membrane that anchors epithelial cells to the underlying connective tissue. Laminin-332 is essential for maintaining skin integrity, wound healing, and epithelial adhesion. The protein forms heterotrimeric complexes with alpha-3 and gamma-2 chains.Mutations in LAMB3 cause junctional epidermolysis bullosa (JEB), a severe blistering skin disease where the epidermis separates from the dermis. Both Herlitz (lethal) and non-Herlitz forms can result from LAMB3 mutations. Common variants may also influence skin integrity, wound healing capacity, and basement membrane function.
Understanding your LAMB3 genetic status provides insights into basement membrane structure and epithelial adhesion. This information is relevant for understanding skin fragility, wound healing capacity, and hereditary skin conditions for family planning purposes.