Gene IFNL3
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Also known as
IL28B, interferon lambda 3, IL-28B, cytokineOverview
IFNL3 (Interferon Lambda 3), also known as IL28B, encodes a type III interferon that plays a crucial role in antiviral immunity, particularly at mucosal surfaces. Unlike type I interferons, type III interferons act primarily on epithelial cells in the respiratory and gastrointestinal tracts, providing frontline defense against viral infections.The rs12979860 polymorphism near IFNL3 is one of the strongest predictors of response to interferon-based therapy for hepatitis C virus (HCV) infection. Individuals with the favorable CC genotype are much more likely to achieve sustained virological response. Although direct-acting antivirals have largely replaced interferon therapy, IFNL3 genotype remains relevant for understanding natural HCV clearance and immune responses to other viruses.
Understanding your IFNL3 genetic status provides insights into antiviral immune capacity. This information is relevant for hepatitis C management and may indicate broader antiviral immunity patterns.