Gene GR
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Also known as
NR3C1, glucocorticoid receptor, GCR, GRLOverview
GR (Glucocorticoid Receptor), officially known as NR3C1, encodes a nuclear receptor that binds cortisol and other glucocorticoid hormones. Upon hormone binding, the receptor translocates to the nucleus and regulates transcription of numerous target genes involved in metabolism, immune function, stress response, and development. GR is expressed in virtually all tissues and mediates the diverse effects of glucocorticoids throughout the body.Variants in GR can affect receptor sensitivity to cortisol, influencing stress response, metabolic regulation, and immune function. The N363S and BclI polymorphisms have been associated with altered glucocorticoid sensitivity, affecting body composition, blood pressure, and inflammatory responses. These variants may influence susceptibility to stress-related disorders and metabolic syndrome.
Understanding your GR genetic status provides insights into glucocorticoid signaling and stress hormone sensitivity. This information is relevant for understanding stress response patterns, metabolic tendencies, and potentially guiding approaches to stress management and inflammatory conditions.