Gene GIPR
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Also known as
gastric inhibitory polypeptide receptor, glucose-dependent insulinotropic polypeptide receptorOverview
GIPR (Gastric Inhibitory Polypeptide Receptor) encodes the receptor for GIP (glucose-dependent insulinotropic polypeptide), an incretin hormone released from the gut after eating. When GIP binds to GIPR on pancreatic beta cells, it stimulates insulin secretion in a glucose-dependent manner, helping regulate blood sugar after meals.Variants in GIPR have been associated with body mass index, type 2 diabetes risk, and glucose homeostasis in genome-wide association studies. Interestingly, some GIPR variants that reduce receptor function are associated with lower BMI, suggesting that GIP signaling promotes fat storage. The dual GIP/GLP-1 receptor agonist tirzepatide has emerged as an effective treatment for obesity and diabetes, highlighting the importance of the GIP pathway.
Understanding your GIPR genetic status provides insights into incretin signaling and metabolic regulation. This information may be relevant for understanding individual responses to dietary interventions and for predicting response to emerging incretin-based therapies for obesity and diabetes.