Gene GAD1
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Also known as
GAD67, SCP, glutamate decarboxylase 1Overview
GAD1 (Glutamate Decarboxylase 1) encodes the enzyme GAD67, which catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA), the brain's primary inhibitory neurotransmitter. GAD67 is responsible for the majority of GABA synthesis in the brain and is essential for maintaining the balance between neuronal excitation and inhibition.Variants in GAD1 have been associated with anxiety disorders, schizophrenia, bipolar disorder, and autism spectrum disorders. Reduced GAD67 expression is one of the most consistent findings in postmortem brain studies of schizophrenia. The enzyme requires pyridoxal phosphate (vitamin B6) as a cofactor, linking B6 status to GABA production and mental health.
Understanding your GAD1 genetic status provides insights into GABA synthesis capacity and potential susceptibility to anxiety and mood disorders. This information may guide consideration of B6 supplementation and GABA-supportive nutrients for individuals with variants affecting enzyme function.