Gene G6PD

Also known as

G6PD1, glucose-6-phosphate dehydrogenase, favism

Overview

G6PD (Glucose-6-Phosphate Dehydrogenase) encodes a key enzyme in the pentose phosphate pathway that generates NADPH, essential for protecting cells against oxidative stress. In red blood cells, which lack mitochondria and other NADPH sources, G6PD is the sole producer of NADPH needed to maintain reduced glutathione and prevent hemolysis.

G6PD deficiency is the most common enzyme deficiency worldwide, affecting over 400 million people. It provides some protection against malaria, explaining its prevalence in malaria-endemic regions. Affected individuals may experience hemolytic anemia when exposed to oxidative stressors including certain foods (fava beans, causing "favism"), medications (antimalarials, sulfonamides, aspirin), and infections. Neonatal jaundice can also occur. The X-linked inheritance means males are more severely affected.

Understanding your G6PD genetic status is critical for medication safety and dietary guidance. Many common drugs can trigger hemolytic crisis in G6PD-deficient individuals, making genetic knowledge essential for preventing potentially life-threatening reactions.

NutraHacker Raw DNA Analysis Products that include this gene

• Carrier Status & Drug Response Report
• Whole Genome Sequencing True Pharmacogenetics Panel

Upload raw DNA data to get your very own analysis of gene G6PD through your personalized DNA reports.