Gene FTO

Also known as

ALKBH9, fat mass and obesity associated

Overview

FTO (FTO Alpha-Ketoglutarate Dependent Dioxygenase) encodes an RNA demethylase that removes methyl marks from N6-methyladenosine (m6A) in mRNA. This gene was the first to be strongly associated with obesity and body mass index in genome-wide association studies, earning it the nickname "fat gene."

Common variants in the FTO gene, particularly rs9939609, have been consistently associated with increased BMI, obesity risk, and type 2 diabetes across multiple populations. The risk allele is associated with approximately 1.5 kg increased weight per allele and is very common, with over 40% of Europeans carrying at least one risk allele. The mechanism appears to involve increased hunger and reduced satiety signaling.

Importantly, the effect of FTO variants on obesity can be modified by lifestyle factors. Physical activity significantly attenuates the obesity risk associated with FTO risk alleles. Understanding your FTO genetic status can help inform personalized weight management strategies emphasizing the importance of regular exercise.

NutraHacker Raw DNA Analysis Products that include this gene

• Fitness Report
• Lactation Report

Upload raw DNA data to get your very own analysis of gene FTO through your personalized DNA reports.