Gene F5

Also known as

FVL, PCCF, THPH2, coagulation factor V, proaccelerin

Overview

F5 (Coagulation Factor V) encodes a key protein in the blood coagulation cascade. Factor V serves as a cofactor for Factor Xa in the prothrombinase complex, accelerating the conversion of prothrombin to thrombin. This protein is essential for normal hemostasis and clot formation.

The most clinically significant variant is Factor V Leiden (R506Q), which makes Factor V resistant to inactivation by activated protein C. This mutation is the most common inherited cause of thrombophilia, affecting 3-8% of European populations. Carriers have increased risk of venous thromboembolism (VTE), deep vein thrombosis, and pulmonary embolism, especially when combined with other risk factors like oral contraceptives, pregnancy, or surgery.

Understanding your F5 genetic status is critical for assessing thrombotic risk and guiding preventive measures. Individuals with Factor V Leiden may need modified approaches to birth control, hormone therapy, and surgical procedures to minimize clotting risk.

NutraHacker Raw DNA Analysis Products that include this gene

• Carrier Status & Drug Response Report
• Whole Genome Sequencing True Pharmacogenetics Panel

Upload raw DNA data to get your very own analysis of gene F5 through your personalized DNA reports.