Gene F11
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Also known as
FXI, coagulation factor XI, plasma thromboplastin antecedentOverview
F11 (Coagulation Factor XI) encodes a serine protease that participates in the intrinsic pathway of blood coagulation. Factor XI is activated by Factor XIIa and in turn activates Factor IX, amplifying the coagulation cascade. This protein plays an important role in maintaining hemostasis, particularly in response to tissue injury.Deficiency of Factor XI causes hemophilia C (Rosenthal syndrome), a bleeding disorder particularly prevalent in Ashkenazi Jewish populations where carrier frequency can reach 8%. Unlike hemophilia A and B, Factor XI deficiency typically causes mild to moderate bleeding, often only apparent after surgery or trauma. Interestingly, elevated Factor XI levels have been associated with increased risk of venous thromboembolism, making F11 a target for anticoagulant drug development.
Understanding your F11 genetic status is valuable for assessing both bleeding and clotting risk. This information can guide surgical planning and help identify individuals who may benefit from Factor XI monitoring or replacement therapy.