Gene CYP3A4

Also known as

CP33, CP34, CYP3A, CYP3A3, NF-25, P450C3, P450PCN1, cytochrome P450 3A4

Overview

CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4) encodes the most abundant cytochrome P450 enzyme in the human liver and intestine. This enzyme metabolizes approximately 50% of all clinically used drugs, making it the single most important drug-metabolizing enzyme in the human body.

CYP3A4 substrates include statins, calcium channel blockers, immunosuppressants, HIV protease inhibitors, benzodiazepines, and many cancer chemotherapeutics. The enzyme is also responsible for metabolizing endogenous compounds including testosterone, cortisol, and vitamin D. CYP3A4 activity can vary up to 40-fold between individuals due to genetic and environmental factors.

CYP3A4 is highly susceptible to drug-drug interactions. Grapefruit juice, St. John's wort, and many medications can significantly alter CYP3A4 activity. Understanding your CYP3A4 genetic status helps predict drug metabolism rates and potential interactions, enabling safer and more effective medication management.

NutraHacker Raw DNA Analysis Products that include this gene

• Complete Mutation Nutrition Report
• WGS True Pharmacogenetics Panel

Upload raw DNA data to get your very own analysis of gene CYP3A4 through your personalized DNA reports.