Gene CYP2E1
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Also known as
CPE1, CYP2E, P450C2E, cytochrome P450 family 2 subfamily E member 1Overview
CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) encodes an enzyme primarily known for metabolizing ethanol and acetone, but also activates many environmental procarcinogens including nitrosamines, benzene, and carbon tetrachloride. This enzyme generates reactive oxygen species during catalysis, contributing to oxidative stress and potentially to tissue damage.CYP2E1 is induced by alcohol consumption, fasting, diabetes, and obesity. Genetic variants affect enzyme activity and have been studied for associations with alcoholic liver disease, acetaminophen hepatotoxicity, and various cancers. The enzyme's role in acetaminophen metabolism is particularly important, as CYP2E1 converts acetaminophen to a toxic metabolite that causes liver damage in overdose.
Understanding your CYP2E1 genetic status provides insights into alcohol metabolism, susceptibility to certain environmental toxins, and potentially acetaminophen toxicity risk. This information may be relevant for individuals with chronic alcohol use or occupational chemical exposures.