Gene CYP2D6

Also known as

CPD6, CYP2D, P450C2D, P450DB1, cytochrome P450 2D6

Overview

CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6) encodes one of the most clinically important drug-metabolizing enzymes. This enzyme is responsible for metabolizing approximately 25% of all clinically used medications, including antidepressants, antipsychotics, opioids, beta-blockers, and tamoxifen.

CYP2D6 is highly polymorphic, with over 100 known allelic variants resulting in four metabolizer phenotypes: poor metabolizers (PM), intermediate metabolizers (IM), extensive/normal metabolizers (EM), and ultrarapid metabolizers (UM). Poor metabolizers may experience drug toxicity at standard doses, while ultrarapid metabolizers may have reduced drug efficacy or, in the case of prodrugs like codeine, potentially dangerous rapid conversion to active metabolites.

Understanding your CYP2D6 status is essential for personalized medicine. This pharmacogenetic information can guide medication selection and dosing to improve efficacy and reduce adverse effects, particularly for psychiatric medications, pain management, and cancer treatment with tamoxifen.

NutraHacker Raw DNA Analysis Products that include this gene

• Complete Mutation Nutrition Report
• WGS True Pharmacogenetics Panel

Upload raw DNA data to get your very own analysis of gene CYP2D6 through your personalized DNA reports.