Gene CYBA
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Also known as
CGD4, p22-phox, cytochrome b-245 alpha chainOverview
CYBA (Cytochrome B-245 Alpha Chain) encodes p22-phox, an essential component of NADPH oxidases that generate reactive oxygen species (ROS). The protein is required for stability and function of NOX1-4 enzymes, which play important roles in host defense, vascular function, and cell signaling.Mutations in CYBA cause a form of chronic granulomatous disease (CGD), a primary immunodeficiency characterized by severe, recurrent bacterial and fungal infections due to defective phagocyte oxidative burst. Common variants in CYBA have been associated with cardiovascular disease risk, hypertension, and oxidative stress-related conditions. The C242T polymorphism affects NADPH oxidase activity and vascular superoxide production.
Understanding your CYBA genetic status provides insights into oxidative stress balance and cardiovascular risk. Variants affecting NADPH oxidase function may influence antioxidant needs and susceptibility to atherosclerosis and other oxidative stress-mediated conditions.