Gene CHDH

Also known as

CHD, choline dehydrogenase

Overview

CHDH (Choline Dehydrogenase) encodes a mitochondrial enzyme that catalyzes the first step in converting choline to betaine. This pathway is important for one-carbon metabolism, providing methyl groups for homocysteine remethylation and synthesis of S-adenosylmethionine (SAM), the universal methyl donor for DNA, proteins, and neurotransmitters.

Variants in CHDH affect choline metabolism and may influence dietary choline requirements. The rs9001 and rs12676 polymorphisms have been associated with altered choline status and potentially increased susceptibility to choline deficiency when dietary intake is inadequate. Choline deficiency can cause fatty liver, muscle damage, and potentially affect fetal brain development during pregnancy.

Understanding your CHDH genetic status helps inform personalized nutrition recommendations for choline intake. Individuals with low-function variants may benefit from ensuring adequate dietary choline through foods like eggs, liver, and legumes, or through supplementation, particularly during pregnancy and lactation when choline demands are increased.

NutraHacker Raw DNA Analysis Products that include this gene

• Complete Mutation Nutrition Report
• Lactation Report

Upload raw DNA data to get your very own analysis of gene CHDH through your personalized DNA reports.