Gene BHMT

Also known as

betaine-homocysteine S-methyltransferase

Overview

BHMT (Betaine-Homocysteine S-Methyltransferase) encodes an enzyme that catalyzes the conversion of homocysteine to methionine using betaine as a methyl donor. This represents an alternative pathway for homocysteine remethylation, independent of the folate-dependent pathway catalyzed by methionine synthase (MTR).

BHMT is primarily expressed in the liver and kidneys and plays a crucial role in maintaining healthy homocysteine levels. When folate-dependent remethylation is compromised (such as in individuals with MTHFR variants), the BHMT pathway becomes increasingly important. Betaine, also known as trimethylglycine (TMG), is the primary methyl donor for this reaction.

Understanding your BHMT genetic status can inform methylation support strategies. Individuals with BHMT variants may benefit from betaine supplementation to support homocysteine metabolism. The BHMT pathway is particularly active when choline and betaine intake is adequate.

NutraHacker Raw DNA Analysis Products that include this gene

• Lactation Report

Upload raw DNA data to get your very own analysis of gene BHMT through your personalized DNA reports.