Gene APOB

Also known as

apoB-100, apoB-48, LDLCQ4, FCHL2

Overview

APOB (Apolipoprotein B) encodes apolipoprotein B, the primary protein component of low-density lipoprotein (LDL) particles. ApoB is essential for the assembly, secretion, and metabolism of LDL and very-low-density lipoprotein (VLDL), making it a central player in cholesterol transport and cardiovascular disease risk.

Mutations in APOB can cause familial hypobetalipoproteinemia (low LDL) or familial hypercholesterolemia (high LDL). The former is characterized by reduced LDL cholesterol and may provide cardiovascular protection, while the latter significantly increases heart disease risk. Importantly, APOB mutations causing familial hypercholesterolemia affect the LDL receptor binding domain, preventing normal clearance of LDL from blood.

ApoB level is considered by many experts to be a better predictor of cardiovascular risk than LDL cholesterol, as each atherogenic particle contains exactly one apoB molecule. Understanding your APOB genetic status can inform cardiovascular risk assessment and guide lipid-lowering therapy decisions.

NutraHacker Raw DNA Analysis Products that include this gene

• Carrier Status & Drug Response Report
• Complete Mutation Nutrition Report
• Whole Genome Sequencing Critical Genetics Report

Upload raw DNA data to get your very own analysis of gene APOB through your personalized DNA reports.