Gene ANKK1
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Also known as
PKK2, SGK288Overview
ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1) encodes a serine/threonine kinase that is part of the receptor-interacting protein kinase family. This gene is located adjacent to the DRD2 dopamine receptor gene and contains the well-known Taq1A polymorphism (rs1800497) that was historically attributed to DRD2.The ANKK1 Taq1A variant has been extensively studied in relation to dopaminergic function and reward processing. The A1 allele (T allele at rs1800497) has been associated with reduced dopamine D2 receptor density in the striatum, which may influence reward sensitivity, addiction vulnerability, and response to dopaminergic medications. Studies have linked this variant to various conditions including substance use disorders, obesity, and impulsive behaviors.
Understanding your ANKK1 genetic status can provide insights into dopamine-related traits and may be relevant for personalized approaches to addiction treatment, weight management, and mental health. The gene's role in signal transduction pathways also makes it relevant to neurological function.