Gene AMBN
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Also known as
AIH2, ameloblastin, sheathlinOverview
AMBN (Ameloblastin) encodes ameloblastin, a major non-amelogenin enamel matrix protein secreted by ameloblasts during tooth development. This protein is essential for proper enamel formation, helping to regulate enamel crystal growth and maintaining ameloblast cell adhesion to the developing enamel surface.Mutations in AMBN cause a form of amelogenesis imperfecta, a group of hereditary disorders characterized by defective enamel formation. Affected individuals typically have teeth with thin, poorly mineralized enamel that is prone to wear, discoloration, and increased sensitivity. The condition can affect both primary and permanent teeth.
Understanding your AMBN genetic status is particularly relevant for dental health assessment. Individuals with AMBN variants may benefit from enhanced preventive dental care, including fluoride treatments, sealants, and regular monitoring. Knowledge of genetic enamel defects can help dental professionals provide appropriate interventions.