Gene ACAT2

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Also known as

ACAT-2, SOAT2

Overview

ACAT2 (Acetyl-CoA Acetyltransferase 2) encodes a cytoplasmic enzyme primarily expressed in the liver and intestine that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-CoA. This esterification is essential for the assembly of lipoproteins and the absorption of dietary cholesterol.

ACAT2 plays a significant role in lipid metabolism and is a key determinant of plasma cholesterol levels. The enzyme is involved in packaging cholesterol into VLDL particles in the liver and into chylomicrons in the intestine. Genetic variants in ACAT2 have been associated with variations in cholesterol absorption efficiency and may influence cardiovascular disease risk.

ACAT2 has been investigated as a potential therapeutic target for reducing atherosclerosis and cardiovascular disease. Understanding your ACAT2 genetic status may provide insights into your cholesterol metabolism and help guide dietary and lifestyle interventions for cardiovascular health.

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