Gene ABCG2

Also known as

BCRP, MXR, ABCP, CDw338, BCRP1

Overview

ABCG2 (ATP Binding Cassette Subfamily G Member 2) encodes the breast cancer resistance protein (BCRP), an important efflux transporter expressed in various tissues including the intestine, liver, kidney, placenta, and blood-brain barrier. This protein plays a key role in protecting the body from xenobiotics and toxins by actively pumping them out of cells.

ABCG2 is clinically significant for its role in drug disposition and pharmacokinetics. It affects the absorption, distribution, and elimination of many medications including statins, chemotherapy drugs, and certain antibiotics. The common Q141K variant (rs2231142) reduces transporter function and is associated with increased drug exposure, higher risk of statin-induced myopathy, and elevated uric acid levels leading to gout.

Understanding your ABCG2 genetic status can help optimize medication dosing and reduce adverse drug reactions. It is particularly relevant for individuals taking rosuvastatin or other BCRP substrates, where dose adjustments may be warranted based on genotype.

NutraHacker Raw DNA Analysis Products that include this gene

• Lactation Report
• WGS True Pharmacogenetics Panel

Upload raw DNA data to get your very own analysis of gene ABCG2 through your personalized DNA reports.