Factor XI Deficiency

Factor XI Deficiency, also known as Hemophilia C or Rosenthal syndrome, is an inherited bleeding disorder caused by reduced levels or activity of blood clotting factor XI. Unlike hemophilia A and B, Factor XI deficiency is generally milder and affects males and females equally.

The condition is particularly common among Ashkenazi Jews, with a carrier frequency of about 8-9% in this population. However, it has been identified in all ethnic groups. The severity of bleeding symptoms does not correlate well with factor XI levels, making it difficult to predict who will have bleeding problems.

Spontaneous bleeding is rare in Factor XI deficiency. Instead, bleeding typically occurs after trauma, surgery, or dental procedures. Common manifestations include prolonged bleeding after surgery, excessive bleeding after tooth extraction, easy bruising, nosebleeds, and heavy menstrual periods in women. Joint and muscle bleeds, common in hemophilia A and B, are rare in Factor XI deficiency.

Factor XI deficiency is caused by mutations in the F11 gene and is inherited in an autosomal pattern. Individuals with two mutated copies (homozygous) or two different mutations (compound heterozygous) typically have the most severe symptoms, while heterozygous carriers may have mild bleeding or be asymptomatic.

NutraHacker examines the following gene related to Factor XI Deficiency:

• F11

For more information about your own genetic profile as related to Factor XI Deficiency, please check out our NutraHacker Carrier Status and Drug Response Report.

Or to get going without any further delay, upload raw DNA data and find out more about your carrier status today.