Malignant hyperthermia susceptibility

February 1, 2023

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Malignant hyperthermia susceptibility (MHS) is a genetic condition that causes a person to have a life-threatening reaction to certain medications used during general anesthesia. People with MHS are at risk of developing a sudden and severe increase in body temperature, muscle rigidity, and rapid heartbeat, known as a malignant hyperthermia (MH) crisis. This reaction can cause damage to the muscles and organs, and can be life-threatening if not treated promptly. MHS is caused by mutations in genes involved in the regulation of muscle contraction, including the RYR1 and CACNA1S genes. The diagnosis of MHS is usually made through a combination of genetic testing, medical history, and physical exam, as well as through muscle biopsy and a sensitivity test. Management may include avoiding certain triggers and having a plan in place for prompt treatment in case of an MH crisis. Individuals with MHS and their families should also be aware of the risk of MH and the importance of proper management during surgical procedures and general anesthesia.

NutraHacker examines the following genes related to Malignant hyperthermia susceptibility:

For more information about your own genetic profile as related to Malignant hyperthermia susceptibility, please check out our NutraHacker Critical Genetics Basic Report Description.

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