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Also known as2OST
UST (urotensin II precursor) is a gene that codes for the UST protein, also known as urotensin II. Urotensin II is a cyclic undecapeptide that is structurally related to the family of corticotropin-releasing factor (CRF) and it is a potent vasoconstrictor, it can also stimulate the release of various vasoactive substances.
Urotensin II is primarily produced and secreted by the hypothalamus and the dorsal root ganglia, it acts as a neurotransmitter and a hormone throughout the body. Urotensin II is involved in the regulation of various physiological processes such as blood pressure, heart rate, insulin secretion, and cell proliferation.
Urotensin II is also involved in the regulation of certain psychiatric and neurological disorders such as anxiety, depression, and schizophrenia. Studies have suggested that the UST protein may be a potential therapeutic target for the development of new treatments for these disorders, particularly for hypertension and cardiovascular disease.
Urotensin II is also a potential target for the treatment of cancer and inflammation.
It is worth mentioning that the UST gene is located on the chromosome 12 and it is a member of the urotensin II/CRF family of genes.