Also known asG0S8
RGS2 (Regulator of G protein signaling 2) is a gene that codes for the RGS2 protein, which is a member of the Regulator of G protein Signaling (RGS) family of proteins. RGS proteins are a group of proteins that play a key role in regulating the activity of G protein-coupled receptors (GPCRs), which are a large family of cell surface receptors that mediate the majority of cellular signaling in the body.
RGS2 acts as a GTPase-activating protein (GAP) for G protein alpha subunits. It increases the rate of GTP hydrolysis, which inactivates the G protein and terminates the signaling pathway.
RGS2 modulates the activity of various G protein-coupled receptors involved in the regulation of the cardiovascular system, the respiratory system, the nervous system and the immune system. RGS2 is involved in the regulation of various physiological processes such as blood pressure, heart rate, insulin secretion, and cell proliferation.
Studies have suggested that variations in the RGS2 gene may be associated with an increased risk of certain cardiovascular and metabolic disorders such as hypertension and type 2 diabetes.
RGS2 is also involved in the regulation of certain psychiatric and neurological disorders such as anxiety, depression, and schizophrenia. Studies have suggested that the RGS2 protein may be a potential therapeutic target for the development of new treatments for these disorders.