Also known as

PTC, MTC1, HSCR1, MEN2A, MEN2B, CDHF12, CDHR16, RET-ELE1

Overview

RET (REarranged during Transfection) is a protooncogene that encodes a tyrosine kinase receptor protein. The RET gene is located on chromosome 10q11.2 and is activated in several types of cancer, including medullary thyroid cancer and certain types of lung and colon cancer. Mutations in the RET gene are also associated with certain inherited disorders, such as multiple endocrine neoplasia type 2 and Hirschsprung's disease. These mutations lead to the activation of the RET protein, which can cause uncontrolled cell growth and division, leading to the development of tumors. Targeted therapy for RET-mutant cancer is an active area of research.

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