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Also known as

MSR, cblE


The MTRR gene codes for the production of an enzyme called 5-methyltetrahydrofolate-homocysteine methyltransferase, also known as 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR). This enzyme is involved in the metabolism of folate, which is a B-vitamin that plays a key role in many important physiological processes, including DNA synthesis and the production of red blood cells. Variations in the MTRR gene have been associated with several health conditions, including neural tube defects, a type of birth defect that affects the brain and spine, and an increased risk of cardiovascular disease. Some research has also suggested that the MTRR gene may be involved in the development of certain types of cancer. However, more research is needed to fully understand the role of this gene in health and disease.

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