Gene IL11
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Also known as
AGIF, IL-11Overview
IL11 (Interleukin 11) is a gene that codes for the IL-11 protein, which is a member of the interleukin family of cytokines. Cytokines are a group of signaling molecules that play a key role in the immune response, inflammation, and cell growth and differentiation.
IL-11 is a pleiotropic cytokine that plays a key role in the regulation of hematopoiesis, which is the process of blood cell formation. It promotes the growth and differentiation of various blood cell types including platelets, erythrocytes, and megakaryocytes.
IL-11 also has anti-inflammatory properties and plays a role in the healing of bone fractures by promoting the proliferation and differentiation of osteoblasts and inhibiting the activity of osteoclasts. It also stimulates the growth of epithelial cells and has been shown to inhibit the growth of certain cancer cells.
IL-11 has been used in the treatment of certain bone marrow disorders such as thrombocytopenia, aplastic anemia, and congenital amegakaryocytic thrombocytopenia, and bone disease such as osteoporosis and osteoarthritis.
It's worth mentioning that some studies have suggested that IL-11 may be a potential therapeutic target in certain types of cancer, as well as in chronic inflammation and fibrosis.