Also known asIL1B, IL-1 IL1F2, IL1beta, IL1-BETA
IL-1beta (Interleukin-1 beta) is a gene that codes for the IL-1beta protein, which is a member of the interleukin family of cytokines. Cytokines are a group of signaling molecules that play a key role in the immune response and inflammation.
IL-1beta is a pro-inflammatory cytokine that plays a critical role in the body's response to injury and infection. It is produced by various cells including macrophages, monocytes, and dendritic cells and it can activate the immune system to fight off pathogens and promote tissue repair.
IL-1beta is involved in the regulation of a wide range of physiological processes including fever, acute-phase response, and inflammatory response, it also modulate the function of other immune cells and organ systems.
Elevated levels of IL-1beta have been associated with a number of inflammatory and autoimmune diseases such as rheumatoid arthritis, Crohn's disease, psoriasis, and multiple sclerosis. In addition, IL-1beta has been linked to the development of certain types of cancer and metabolic disorders such as obesity and diabetes.
Drugs that target IL-1beta, such as anakinra and canakinumab, are used to treat certain inflammatory and auto-inflammatory diseases such as rheumatoid arthritis, juvenile idiopathic arthritis, and cryopyrin-associated periodic syndromes.