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Also known asGLUR3, GLURC, GluA3, MRX94, MRXSW, GLUR-C, iGluR3, GLUR-K3
GRIA3 (glutamate receptor, ionotropic, AMPA 3A) is a gene that codes for the AMPA type of ionotropic glutamate receptor 3A (GRIA3A), also known as GluA3. This gene is part of a family of ionotropic glutamate receptors, which are responsible for the majority of fast synaptic excitation in the brain. These receptors play a key role in the regulation of the central nervous system by modulating the flow of ions, particularly calcium, across the cell membrane in response to the neurotransmitter glutamate.
The AMPA receptors, of which GRIA3A is a member, are responsible for the majority of fast synaptic excitation in the brain. These receptors are activated by the neurotransmitter glutamate, which is involved in many important brain functions such as memory, learning, and synaptic plasticity.
Studies have suggested that variations in the GRIA3 gene may be associated with an increased risk of certain neurological and psychiatric disorders such as schizophrenia, depression, and bipolar disorder. The GRIA3 gene has also been linked to the development of certain neurological disorders such as epilepsy and Alzheimer's disease, as well as addiction and alcoholism.
It is also worth mentioning that GRIA3 is a target for some drugs such as AMPA receptor agonists and antagonists, which modulate the activity of this receptor. These drugs are being developed as potential treatments for neurological and psychiatric disorders.