Also known as
GPx-P, GSHPx-3, GSHPx-P
GPX3 is a gene that encodes a protein called glutathione peroxidase 3. Like glutathione peroxidase 1 (GPX1), this protein is an antioxidant enzyme that helps to protect cells and tissues from oxidative stress. It plays a critical role in the body's defense against free radicals and other reactive oxygen species, which can cause damage to cellular components such as DNA, proteins, and lipids.
Glutathione peroxidase 3 is found in many tissues throughout the body, including the liver, kidney, spleen, and pancreas. It is expressed at highest levels in the liver and is involved in a number of important physiological processes, including the detoxification of xenobiotics (foreign chemicals that enter the body), the regulation of immune function, and the maintenance of structural integrity of cell membranes. Like GPX1, deficiencies in GPX3 activity have been linked to a number of health conditions, including cardiovascular disease, cancer, and neurological disorders.
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