Also known as
Folate receptor 3, FR-gamma, Folate receptor gamma
Overview
FOLR3 (Folate Receptor 3) is a gene that encodes a member of the folate receptor family, which are glycosylphosphatidylinositol (GPI)-anchored cell surface proteins that facilitate cellular uptake of folate. Unlike FOLR1 and FOLR2, FOLR3 has a secreted isoform and is primarily expressed in hematopoietic cells. Folate is an essential B vitamin required for one-carbon metabolism, DNA synthesis, methylation reactions, and cell division. The folate receptor family enables cells to capture and internalize folate from the extracellular environment through receptor-mediated endocytosis. FOLR3 expression has been detected in various immune cells and may play a role in immune function. While less well-characterized than other folate receptors, FOLR3 may contribute to folate homeostasis and cellular folate status, which is critical for rapidly dividing cells and metabolic health. Variants in folate-related genes may influence folate metabolism, methylation capacity, and cellular proliferation.
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