Gene FKBP5

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Also known as

AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10


FKBP5 (FK506 binding protein 5) is a gene that codes for the FK506-binding protein 5 (FKBP5) protein. The FKBP5 protein is a member of the FK506-binding protein (FKBP) family, which is known to be involved in the regulation of the immune system and the stress response.

The FKBP5 protein acts as a co-chaperone of the glucocorticoid receptor (GR), a transcription factor that plays a key role in the regulation of the stress response by modulating the expression of genes involved in the stress response. The FKBP5 protein modulates the activity of the GR by increasing its sensitivity to the hormone cortisol and by controlling its localization in the cell.

Variations in the FKBP5 gene have been associated with an increased risk of certain mental health conditions such as anxiety and depression, particularly in individuals exposed to traumatic or stressful events. Studies have suggested that the FKBP5 gene may also play a role in the development of post-traumatic stress disorder (PTSD) and in the response to stress-related treatments such as glucocorticoid therapy.

It is worth mentioning that FKBP5 has also been studied in relation to cardiovascular disease, cancer, and bone metabolism.

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