Also known as
ADAI, AI1C, AIH2
ENAM is the gene that codes for the protein enamelin, which is a key component of the extracellular matrix of developing teeth. Enamelin is involved in the formation of enamel, the hard, protective outer layer of the tooth. It is expressed in the cells called ameloblasts that are responsible for forming enamel during tooth development. Enamelin is also expressed in other tissues, including the hair and nails. Mutations in the ENAM gene can cause defects in enamel development, leading to conditions such as amelogenesis imperfecta, a disorder that affects the structure and function of teeth. Enamelin is one of the proteins that make up the extracellular matrix of developing teeth, and it is thought to play a role in the organization and orientation of the enamel crystals. It is also thought to have a role in regulating the activity of other proteins involved in enamel formation.
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