Gene EDN1

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Also known as



EDN1 (Endothelin 1) is a gene that codes for a protein called endothelin 1, which is a vasoconstrictor peptide that regulates blood vessel tone and plays a role in various physiological processes, including cardiovascular function and tissue repair.

The EDN1 gene is located on chromosome 6 in humans and consists of five exons. The protein encoded by the gene is synthesized as a precursor protein that is cleaved to produce the mature endothelin 1 peptide.

Endothelin 1 is a potent vasoconstrictor that acts on endothelin receptors located on the smooth muscle cells of blood vessels. It regulates blood vessel tone and plays a role in the regulation of blood pressure and blood flow to various organs and tissues.

In addition to its vasoconstrictive properties, endothelin 1 has been shown to have other physiological functions, including the promotion of cell proliferation and tissue repair. Dysregulation of endothelin 1 has been implicated in the pathogenesis of various cardiovascular and renal diseases, including hypertension, atherosclerosis, and renal failure.

Overall, the EDN1 gene and its encoded protein play critical roles in the regulation of blood vessel tone and various physiological processes. Its study has potential implications for understanding and treating various cardiovascular and renal diseases related to endothelin 1 production and function.

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