Also known asD2DR, D2R
DRD2 (dopamine receptor D2) is a gene that codes for the dopamine receptor D2 (DRD2) protein. The DRD2 protein is a G protein-coupled receptor found in the brain and other parts of the body, and it plays a role in the regulation of dopamine, a neurotransmitter that is involved in many important brain functions such as mood, motivation, and movement. The DRD2 receptor is expressed in many regions of the brain, including the striatum, nucleus accumbens, olfactory tubercle, and substantia nigra.
Variations in the DRD2 gene have been associated with a number of conditions, including addiction, schizophrenia, and Parkinson's disease. Lower levels of DRD2 have been linked with addiction and impulse control disorders, while higher levels have been associated with schizophrenia and certain mood disorders. DRD2 is a target for many drugs, such as antipsychotics and anti-addiction drugs, which modulate the activity of this receptor.
Some studies suggest that DRD2 gene variants may also influence the response to certain medications and therapies, and DRD2 genotyping may be used in the future to personalize treatment for certain psychiatric disorders.