Also known as
CPCJ, CYP2C, P450C2C, CYPIIC17, CYPIIC19, P450IIC19
CYP2C19 is a gene that provides instructions for making a enzyme called cytochrome P450 2C19. This enzyme is involved in the metabolism of several drugs, including some antidepressants, antiepileptic drugs, and proton pump inhibitors used to treat acid reflux. It is also involved in the metabolism of several other compounds, such as the hormone estrogen and the neurotransmitter serotonin.
Variations, or polymorphisms, in the CYP2C19 gene can affect the activity of the enzyme that it encodes. Some people have a version of the gene that codes for a more active enzyme, while others have a version that codes for a less active enzyme. This can affect the way that drugs are metabolized in the body and can influence an individual's response to certain medications.
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