Gene CYP1A2

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Also known as

CP12, CYPIA2, P3-450, P450(PA)


CYP1A2 (cytochrome P450 1A2) is a member of the cytochrome P450 family of enzymes. These enzymes are responsible for the metabolism of a wide range of substances, including drugs, hormones, and toxins. CYP1A2 is expressed in the liver and is involved in the metabolism of many drugs, including caffeine, theophylline, and some antidepressants. It is also involved in the metabolism of carcinogens and other toxic compounds.

Variations in the CYP1A2 gene can affect an individual's ability to metabolize certain drugs and toxins, which can have an impact on their response to treatment and their risk of side effects. Some people have a slower-than-average metabolism of CYP1A2, which can lead to a buildup of drugs in their system and an increased risk of side effects. Others may have a faster-than-average metabolism, which can lead to a reduced effectiveness of certain medications. It is important for healthcare providers to be aware of an individual's CYP1A2 metabolism when prescribing and dosing medications.

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