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Also known asCREB, CREB-1
CREB1 (Cyclic AMP Response Element Binding Protein 1) is a gene that codes for a protein called CREB, which is a transcription factor that binds to specific DNA sequences and regulates the expression of target genes. CREB1 is involved in a variety of physiological processes, including learning and memory, circadian rhythms, and glucose homeostasis.
The CREB1 gene is located on chromosome 2 in humans and consists of 11 exons. The protein encoded by the gene contains several functional domains, including a DNA-binding domain, a leucine zipper domain, and a transcriptional activation domain. CREB1 is activated by various signaling pathways, including the cAMP/PKA pathway and the MAPK/ERK pathway.
CREB1 is known to regulate the expression of numerous target genes involved in various physiological processes, including neurotransmitter synthesis and release, synaptic plasticity, and glucose metabolism. Dysregulation of CREB1 has been implicated in the pathogenesis of various disorders, including addiction, depression, and cancer.
Studies have also suggested that CREB1 plays a role in the response to stress, both physical and psychological. It has been shown to be involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is a key component of the body's response to stress.
Overall, the CREB1 gene and its encoded protein play critical roles in the regulation of gene expression and various physiological processes. Its study has potential implications for understanding and treating various disorders and conditions related to gene expression and cellular signaling.