Gene CNR2

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Also known as

CB-2, CB2, CX5


The CNR2 gene encodes the cannabinoid receptor 2 (CB2), a G protein-coupled receptor that is activated by endocannabinoids and phytocannabinoids (compounds found in the marijuana plant). CB2 receptors are primarily found in the immune system but also present in other organs and tissues, such as the brain, heart, and adipose tissue.

Activation of CB2 receptors modulate various physiological processes such as inflammation, pain perception, and immune function. CB2 receptors are involved in the regulation of the immune system and play a role in the development of immune-mediated disorders such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. Genetic variation in the CNR2 gene has been associated with increased risk for some immune-mediated disorders.

CB2 receptors are also being studied as potential therapeutic targets for the treatment of chronic pain, inflammation, and cancer. Activation of CB2 receptors has been shown to have anti-inflammatory and anti-cancer effects and could be used as a potential therapy for these diseases.

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