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Also known asCANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR
The CNR1 gene encodes the cannabinoid receptor 1 (CB1), a member of the G protein-coupled receptor family. CB1 receptors are primarily found in the central nervous system (CNS) but also present in other organs and tissues, such as the liver, adipose tissue, and reproductive organs. CB1 receptors are activated by endocannabinoids, which are naturally occurring compounds in the body, as well as by the psychoactive component of marijuana, delta-9-tetrahydrocannabinol (THC). Activation of these receptors modulate various physiological processes such as appetite, pain perception, mood, and memory.
The CB1 receptors play a role in the regulation of neurotransmitters such as dopamine and serotonin which are involved in the development of mood disorders. Genetic variation in the CNR1 gene has been associated with increased risk for obesity, type 2 diabetes, and marijuana use disorder. The CNR1 gene is also a target for the development of therapeutics for the treatment of pain, obesity, and other disorders such as drug addiction and psychiatric conditions.