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Also known as

KAT13D, bHLHe8


The CLOCK (Circadian Locomotor Output Cycles Kaput) gene encodes a protein that plays a central role in the regulation of the body's internal clock, or circadian rhythm. The CLOCK protein is part of a complex called the positive transcriptional activator loop (CLOCK/BMAL1), which is involved in the transcription of several genes that are important for maintaining the body's circadian rhythm. The CLOCK/BMAL1 complex works in conjunction with other clock genes, including PER and CRY, to regulate the expression of clock-controlled genes and maintain a consistent circadian rhythm. Dysregulation of the CLOCK gene has been linked to a variety of disorders, including insomnia, depression, and cardiovascular disease.

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